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flow trial semaglutide kidney outcomes nejm 2024 hazard ratio 0.76 In the FLOW trial, researchers assessed whether the glucagon-like peptide 1 receptor agonist semaglutide was effective in preventing progression of kidney disease in patients with type 2 diabetes and chronic kidney disease

Marsoni M251S
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4.3 ★★★★★
Based on 151 reviews
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Verified Purchase
Laura E.
Natrona Heights, US
★★★★★ 1
A treat, not a chewing bone. Lasts only a few minutes.
Short lived - lasts only a few minutes with our Golden's. I have used other products like Natural Pet collagen rolls which last a VERY long time with our voracious chewers.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on November 28, 2025
P
Verified Purchase
PS
Draper, US
★★★★★ 3
Not a happy customer
My Aussie ate the chew stick within 5min. Disappointed it didn't last longer. Won't buy again :(
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Reviewed in the United States on May 27, 2026
Y
yetanothereviewer
Birmingham, US
★★★★★ 4
Massive treats, no tummy rumbles, but a little pricey
I'm always a little tentative when ordering dog treats online, because you don't always know in advance where they're sourced from, or what weird processing might be done to them, or what weird additives might be thrown in. These are sourced in Mexico, and they seem to be straightforward in terms of ingredients. Phew! The smell of these is not the best, but if you've fed your dog collagen treats before, I'm sure you know what you're getting into with that. The dogs loved them, for sure. These treats are MASSIVE, so if you have a small or medium sized dog, you might want to cut them into two or more pieces. For my 60ish pound dogs, they were very large but manageable, and the way their eyes lit up when I presented it to them, it was like Christmas. LOL The only reason I'm docking a star is because these are not long-term chews, at least for my dogs. Yak chews will generally last for a couple of hours for them, which I break up over several days by taking the treat away after a while and giving it back to them the next day. These chews were gone within about 5-10 minutes. (Five minutes for my spazzy dog who acts like treats will disappear if they're not hoovered it into her gullet at breakneck speed, and ten minutes for the other who likes to taste his food on the way down.) At almost $6 a pop, these are pretty expensive for 5-10 minutes of enjoyment, so this isn't going to be a treat I buy for them on the regular. There were no issues with tummy rumbles or nausea or diarrhea afterward, so that's good. And I like getting a little more collagen in these kids because they're both getting up there in age, so their hips and joints can use a little extra love. If you've got the extra money to spring for these, or if your dog paces him- or herself reasonably with dog treats, this could be a good choice for you.
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Reviewed in the United States on September 8, 2025
W
Verified Purchase
Willow
Boise, US
★★★★★ 5
My non-chewer loves these
He is not into chewing, tried many different ones. But he’ll chomp down on theses, and they seem to be all good stuff
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Reviewed in the United States on December 17, 2025
M
M.S.
Waukegan, US
★★★★★ 5
Dog loves them, no rawhide!
My dog is obsessed with these! We have a 70 pound pit mix who is a power chewer and these rolls last forever. He goes crazy for the peanut butter taste and it takes him a couple of days to really destroy one entirely. They are very effective for keeping him busy as the size is massive. I like giving him something so large because he then sets his mind to it for a long time. I like that they have a lot of collagen in them, I can't say I've noticed that his coat is a great deal shinier but it can't hurt! I also like that these are rawhide free. I would say these are a good value as they keep him busy for a good amount of time.
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Reviewed in the United States on January 29, 2026

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