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A study in Nature Health analyzes Reddit posts between 2019 and 2025 that mentioned semaglutide or tirzepatide and finds a spectrum of associated reported side effects extending beyond the commonly known safety
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67,000 people on semaglutide (Wegovy) or tirzepatide (Mounjaro). 410,198 Reddit posts. Analysed by the University of Pennsylvania and published in Nature Health, April 2026. 43.5% reported at least one side effect. The
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